Levofloxacin is a fluoroquinolone antimicrobial that shows antimicrobial activity by inhibiting bacterial topoisomerase II (DNA Gyrase) and topoisomerase IV, enzymes required for DNA replication, transcription, repairing and recombination. Levofloxacin has wide spectrum of activities against different Gram-Positive bacteria e.g., Corynebacteriium species, Staphylococcus aureus, Staphylococcus epidermis, Streptococcus pneumoniae, Stereptococci Group C/F, Streptococci Group G, Viridans group streptococci and Gram-Negative bacteria e.g., Pseudomonas aeruginosa, Acinetobacter lowffii, Haemophilus influenzae, Serratia marcescens.