Baclofen is an effective muscle relaxant and antispastic agent with a spinal site of action. It inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating GABAB receptors, which inhibit the release of glutamate and aspartate. It may also act at intraspinal sites, producing CNS depression. Neuromuscular transmission is not affected by Baclofen. Additionally, Baclofen exerts an antinociceptive effect.

Myorel® is indicated for:
Muscle spasm
Tension-type headache
Alleviation of spasticity resulting from multiple sclerosis
Spinal cord diseases
Muscle spasm of cerebral origin, especially infantile cerebral palsy
Cerebrovascular accidents, neoplastic, or degenerative brain diseases

Adults: The following slowly increasing dosage regimen is suggested but may be adjusted based on the patient’s needs:
5 mg three times a day for 3 days
10 mg three times a day for 3 days
15 mg three times a day for 3 days
20 mg three times a day for 3 days
Doses up to 60 mg per day usually provide satisfactory symptom control, though careful adjustment according to each patient’s needs is often necessary. Smaller, more frequent doses may be more effective than larger, less frequent doses.
If required, the dose may be gradually increased. A maximum daily dose exceeding 100 mg is not recommended unless the patient is hospitalized and under close supervision.
If the maximum recommended dose is reached and no therapeutic benefit is observed within six weeks, continuing Baclofen therapy may not be beneficial.
Children: The recommended dosage range is 0.75 to 2 mg/kg body weight.
For children over 10 years of age, a maximum daily dose of 2.5 mg/kg body weight may be given.
Treatment typically begins with 2.5 mg, four times a day. The dosage should be cautiously increased at approximately three-day intervals until the child's individual requirements are met.

Pregnancy: The safety of Baclofen in pregnant women has not been established. The potential benefits of treatment should be weighed against possible risks.
Lactation: Use of Baclofen in lactating women is not recommended. If therapy is considered essential, an alternative feeding arrangement should be made.

The most common side effects include:
Drowsiness
Nausea
Dizziness
Lassitude (fatigue)
Lightheadedness

Muscular pain and weakness
Hypotension (low blood pressure)

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

Alcohol and other CNS depressants: May exacerbate the CNS effects of Baclofen and should be avoided.
Lithium: May cause severe aggravation of hyperkinetic symptoms.
Ibuprofen and other drugs that cause renal insufficiency: May reduce Baclofen excretion, leading to toxicity.

Baclofen stimulates gastric acid secretion and should be used with caution in patients with a history of peptic ulcer. It should be avoided in those with active peptic ulcer disease.
Baclofen should be used with caution in patients with severe psychiatric disorders, epilepsy, or convulsive disorders, as these conditions may worsen.
Liver function should be monitored in patients with liver disease.
Patients with renal impairment may require a reduced dose.
Baclofen should be used with caution in patients with respiratory impairment.

Store in a cool and dry place below 30°C.
Protect from light.
Medicine: Keep out of reach of children.
